INIBIBB   05455
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE BAHIA BLANCA
Unidad Ejecutora - UE
artículos
Título:
Diet And Age Interactions With Regards To Cholesterol Regulation And Brain Pathogenesis
Autor/es:
URANGA, ROMINA MARÍA; KELLER, JEFFREY NEIL
Revista:
Current Gerontology and Geriatrics Research
Editorial:
Hindawi Publishing Corporation
Referencias:
Lugar: New York, USA; Año: 2010
Resumen:
DIET AND AGE INTERACTIONS WITH REGARDS TO CHOLESTEROL REGULATION AND
BRAIN PATHOGENESIS
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Cholesterol is an
essential molecule for brain homeostasis, yet hypercholesterolemia and its
numerous complications are believed to play a role in promoting multiple
aspects of brain pathogenesis. An ever increasing number of individuals in
modern Western Society are regularly consuming diets high in fat which promote
the development of hypercholesterolemia. Additionally, modern societies are
becoming increasingly aged, causing a collision between increased
hypercholesterolemia and increased aging, which will likely lead to the
development of increased pathological conditions due to hypercholesterolemia,
thereby promoting deleterious neurochemical and behavioral changes in the
brain. Lastly, while beneficial in controlling cholesterol levels, the long
term use of statins itself potentially may promote adverse effects on brain
homeostasis, although specifics on this remain largely unknown. This review
will focus on linking the current understanding of diet induced
hypercholestolemia (as well as statin use) to the development of oxidative
stress, neurochemical alterations, and cognitive disturbances in the aging
brain.