EFFECTS OF Smallanthus sonchifolius LEAVES DECOCTION IN THE PROTECTION OF GASTRIC MUCOSA FROM ETHANOL-INDUCED DAMAGE IN RATS

CABRERA W.M.; TABOADA F. F; GENTA S. B.; HABIB N. C.

Tafí Viejo, Tucumán

Jornada; XXXVI Jornadas Científicas de la Asociación de Biología de Tucumán; 2019

Asociación de Biología de Tucumán

Smallanthus sonchifolius [Poepp. & Ende.] H. Robinson is a perennial herb widely distributed in South America. Their leaves have beenused for centuries to treat digestive diseases. The peptic ulcer is an increasing disorder resulting from the imbalance between protective andaggressive factors in the gastric mucosa. A protective factor enhancer therapy would be an interesting approach to prevent gastric ulcers.The aim of the present study was to evaluate the in vivo gastroprotective effect of the 10% decoction of S. sonchifolius leaves. An ethanolinduced gastric ulcer model in Wistar rats was used. The experimental groups (n=6 animals) were: Normal control group, Negative controlgroup, (NaCl 0.9%), Positive control group (Sucralfate 100 mg/kg orally), and Treated group (S. sonchifolius 10% leaves decoction 150mg/kg orally). Mucus content and ulceration parameters were determined. Histological and histochemical studies of gastric tissue wereperformed. The activity of catalase and the levels of reduced glutathione and malondialdehyde were quantified in gastric homogenates. S.sonchifolius extract caused a significant (p