A novel bone scaffold based on hyperbranched polyglycerol fibers filled with hydroxiapatite nanoparticles: In vitro cell response

A.A.A DE QUEIROZ; J.C. BRESSIANI; A.H. BRESSIANI; O.Z. HIGA; G.A. ABRAHAM

Buzios, Brasil

Simposio; 21st International Symposium of Ceramics in Medicine; 2008

International Society for Ceramics in Medicine (ISCM)

A novel bone scaffolding material was successfully fabricated by electrospinning from hyperbranched polyglycerol (HPGL) solutions containing nanoparticles of hydroxyapatite (HA). The potential use of the electrospun fibrous HPGL-HA scaffolds for bone regeneration was evaluated in vitro with human osteoblasts in terms of alkaline phosphatase (ALP) activity of the cells that were cultured directly on the scaffolds. The results were compared with those on corresponding HPLG-HA solution-cast film scaffolds. It was found that all of the fibrous scaffolds promoted much better adhesion and proliferation of cells than the corresponding film scaffolds.