INTEMA 05428
INSTITUTO DE INVESTIGACIONES EN CIENCIA Y TECNOLOGIA DE MATERIALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Risperidone loaded PCL-PEO-PCL nanospheres: in vitro release results
Autor/es:
LAURA C. HERRERA; LAURA G. HERMIDA; GUSTAVO A. ABRAHAM; FABIÁN BUFFA; PAULINA E. LLORET
Lugar:
Maryland
Reunión:
Congreso; 38th Annual Meeting and Exposition of the Controlled Release Society; 2011
Institución organizadora:
Controlled Release Society
Resumen:
A PCL-PEO-PCL triblock copolymer was synthesized and used to prepare risperidone loaded nanospheres. Emulsifier and drug-polymer concentration were varied to obtain different release systems which were analyzed by AFM and DLS. Encapsulation efficiency and in vitro release profiles were also determined. Encapsulation efficiencies varied depending on the surfactant and the drug-polymer concentration used. Risperidone nanospheres presented a prolonged release except for those prepared with PVA at a high drug-polymer concentration which rapidly released the drug.
