The potentiation effect of iodine species in the antimicrobial capability of surfaces coated with electroactive phthalocyanines

MARTÍNEZ, SOL; DURANTINI, ANDRES M.; DURANTINI JAVIER E.; PALACIOS, YOHANA B.; BAIGORRIA, ESTEFANIA; MILANESIO, M. ELISA

ACS Applied Bio Materials

American Chemical Societya

Año: 2021

2576-6422

The spreading of different infections can occur through direct contact with glasssurfaces in commonly used areas. Incorporating the use of alternative therapies in these materialsseems essential to reduce and also avoid bacterial resistance. In this work, the capability to killmicrobes of glass surfaces coated with two electroactive metallated phthalocyanines (ZnPc-EDOTand CuPc-EDOT) is assessed. The results show that both of these materials are capable ofproducing reactive oxygen species however the polymer with Zn(II) (ZnPc-PEDOT) has a singletoxygen quantum yield 8-fold higher than the Cu(II) containing analogue. This was reflected in thein vitro experiments where the effectiveness of the surfaces was tested in bacterial suspensions,monitoring single microbe inactivation upon attachment to the polymers, and eliminating maturebiofilms. Furthermore, we evaluated the use of an inorganic salt (KI) to potentiate thephotodynamic inactivation mediated by electropolymerized surface. The addition of the saltimproved the efficiency of the phototherapy at least 2 times for both polymers nevertheless thematerial coated with ZnPc-PEDOT was the only one capable of eliminating > 99.98 % of the initialmicrobes loading under different circumstances.