INTEMA   05428
INSTITUTO DE INVESTIGACIONES EN CIENCIA Y TECNOLOGIA DE MATERIALES
Unidad Ejecutora - UE
artículos
Título:
Development and validation of a mechanistic model for the release of embelin from a polycaprolactone matrix
Autor/es:
SEOANE, IRENE TERESITA; TOMBA, P.; SEOANE, IRENE TERESITA; TOMBA, P.; CORTEZ TORNELLO P.R.; ABRAHAM G.A.; CORTEZ TORNELLO P.R.; ABRAHAM G.A.; SILVA, LEONEL; CISILINO ADRIÁN; SILVA, LEONEL; CISILINO ADRIÁN
Revista:
POLYMER TESTING
Editorial:
ELSEVIER SCI LTD
Referencias:
Lugar: Amsterdam; Año: 2020 vol. 91
ISSN:
0142-9418
Resumen:
Embelin is a natural agent with antimicrobial, antifungal and analgesic activities.This work presents a mechanistic model for the release of embelin from a polycaprolactonematrix. Based on the results of embelin release experiments and Raman microscopymeasurements, the model assumes a dual dispersion of the embelin: agglomerated anddispersed. Embelin release mechanism combines the effects of the liquid migration into thematrix, the drug diffusion, and the drug dissolution within the wetted matrix. The model isformulated in terms of four partial differential equations that account for the mass balancesof dispersed, agglomerated, and dissolved embelin, and aqueous solution. Modelpredictions show that the release mechanism involves three stages: a burst stage, in whichdispersed embelin is rapidly released; a transition stage, in which dispersed andagglomerated embelin are simultaneously released; and, once the dispersed embelindepletion, a stable release stage until the agglomerated embelin exhausts.