INTEMA 05428
INSTITUTO DE INVESTIGACIONES EN CIENCIA Y TECNOLOGIA DE MATERIALES
Unidad Ejecutora - UE
artículos
Título:
In vitro and in vivo evaluation of desmopressin-loaded poly( D,L -lactic-co-glycolic acid) nanoparticles for its potential use in cancer treatment
Autor/es:
GARONA, JUAN; ALONSO, DANIEL F; GARONA, JUAN; ALONSO, DANIEL F; SOBOL, NATASHA T; ÁLVAREZ, VERA A; SOBOL, NATASHA T; ÁLVAREZ, VERA A; CHEVALIER, MERARI T; FARINA, HERNAN G; CHEVALIER, MERARI T; FARINA, HERNAN G
Revista:
NANOMEDICINE
Editorial:
FUTURE MEDICINE LTD
Referencias:
Año: 2018 vol. 13 p. 2835 - 2849
ISSN:
1743-5889
Resumen:
AIM:To develop and characterize the antitumor activity of poly(D,L-lactic-co-glycolic acid) nanoparticles loaded with hemostatic and anticancer drug desmopressin (dDAVP).MATERIALS & METHODS:After full physicochemical characterization, anticancer activity of dDAVP-loaded poly(D,L-lactic-co-glycolic acid) nanoparticles (NPdDAVP) was evaluated in vitro and in vivo on a highly aggressive breast cancer model.RESULTS:After efficiently loading desmopressin in poly(D,L-lactic-co-glycolic acid) matrix, NPdDAVP exhibited suitable physicochemical characteristics for biomedical applications. NPdDAVP displayed a potent cytostatic effect in vitro, inhibiting tumor cell proliferation and colony forming ability. Moreover, intravenous treatment using nanoparticulated-dDAVP inhibited tumor progression and prolonged survival in animals bearing rapidly-growing mammary tumors.CONCLUSION:Within the framework of promising dDAVP repurposing studies, these findings support further preclinical development of the NPdDAVP for the management of highly aggressive cancer.
