INIBIOLP 05426
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE LA PLATA "PROF. DR. RODOLFO R. BRENNER"
Unidad Ejecutora - UE
artículos
Título:
Two crystal forms of a helix-rich fatty acid- and retinol-binding protein, Na-FAR-1, from the parasitic nematode Necator americanus.
Autor/es:
GABRIELSEN M; REY-BURUSCO MF; GRIFFITHS K; ROE AJ; COOPER A; SMITH BO; KENNEDY MW; CORSICO B
Revista:
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Londres; Año: 2012 p. 835 - 838
ISSN:
1744-3091
Resumen:
Na-FAR-1 is an unusual α-helix
rich fatty acid and retinol binding protein from Necator americanus, the blood-feeding intestinal parasitic nematode
of humans. It belongs to the FAR protein family that is unique to nematodes and
no structural information is available for FAR proteins from parasites to date.
Crystals were obtained with two different morphologies that corresponded to
different space groups. Crystal form 1 exhibited space group P432 (a=b=c =120.80, α=β=γ=90°) and diffracted to 2.5 Å, whereas crystal form
2 exhibited space group F23 (a=b=c =240.38, α=β=γ=90°) and diffracted to
3.2 Å. Crystal form 2 showed signs of significant twinning.
