INIFTA 05425
INSTITUTO DE INVESTIGACIONES FISICO-QUIMICAS TEORICAS Y APLICADAS
Unidad Ejecutora - UE
artículos
Título:
Freeze-drying of silica nanoparticles: redispersibility toward nanomedicine applications
Autor/es:
MONDO, GABRIELA B; PICCO, AGUSTIN S; CARDOSO, MATEUS B; FERREIRA, LARISSA F; LIBERATO, MICHELLE S
Revista:
NANOMEDICINE
Editorial:
FUTURE MEDICINE LTD
Referencias:
Año: 2018 vol. 13 p. 179 - 190
ISSN:
1743-5889
Resumen:
Aim: To study freeze-drying of silica nanoparticles (SiO2NPs) in order to find suitable conditions to produce lyophilized powders with no aggregation after resuspension and storage. Methods: SiO2NPs were synthesized using a Stöber-based procedure, and characterized by scanning electron microscopy, dynamic light scattering and nitrogen adsorption/desorption isotherms. SiO2NPs hydrodynamic diameters were compared prior and after freeze-drying in the presence/absence of carbohydrate protectants. Results: Glucose was found to be the most suitable protectant against the detrimental effects of lyophilization. The minimum concentration of carbohydrate required to effectively protect SiO2NPs from aggregation during freeze-drying is influenced by the nanoparticle´s size and texture. Negligible aggregation was observed during storage. Conclusion: Carbohydrates can be used during SiO2NPs freeze-drying process to obtain redispersable solids that maintain original sizes without residual aggregation.
