INIFTA   05425
INSTITUTO DE INVESTIGACIONES FISICO-QUIMICAS TEORICAS Y APLICADAS
Unidad Ejecutora - UE
artículos
Título:
LIPID PEROXIDATION OF MEMBRANE PHOSPHOLIPIDS GENERATES HYDROXY-ALKENALS AND OXIDIZED PHOSPHOLIPIDS ACTIVE IN PHYSIOLOGICAL AND/OR PATHOLOGICAL CONDITIONS
Autor/es:
ANGEL CATALA
Revista:
CHEMISTRY AND PHYSICS OF LIPIDS
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Lugar: Netherlands; Año: 2009 vol. 157 p. 1 - 11
ISSN:
0009-3084
Resumen:
Polyunsaturated fatty acids (PUFAs) and their metabolites have a variety of physiological roles including:
energy provision, membrane structure, cell signaling and regulation of gene expression. Lipids containing
polyunsaturated fatty acids are susceptible to free radical-initiated oxidation and can participate in
chain reactions that increase damage to biomolecules. Lipid peroxidation, which leads to lipid hydroperoxide
formation often, occurs in response to oxidative stress. Hydroperoxides are usually reduced to their
corresponding alcohols by glutathione peroxidases. However, these enzymes are decreased in certain diseases
resulting in a temporary increase of lipid hydroperoxides that favors their degradation into several
compounds, including hydroxy-alkenals. The best known of these are: 4-hydroxy-2-nonenal (4-HNE) and
4-hydroxy-2-hexenal (4-HHE), which derive from lipid peroxidation of n-6 and n-3 fatty acids, respectively.
Compared to free radicals, these aldehydes are relatively stable and can diffuse within or even
escape from the cell and attack targets far from the site of the original event. These aldehydes exhibit
great reactivity with biomolecules, such as proteins, DNA, and phospholipids, generating a variety of intra
and intermolecular covalent adducts. At the membrane level, proteins and amino lipids can be covalently
modified by lipid peroxidation products (hydoxy-alkenals). These aldehydes can also act as bioactive
molecules in physiological and/or pathological conditions. In addition this review is intended to provide
an appropriate synopsis of identified effects of hydroxy-alkenals and oxidized phospholipids on cell signaling,
from their intracellular production, to their action as intracellular messenger, up to their influence
on transcription factors and gene expression.
Compared to free radicals, these aldehydes are relatively stable and can diffuse within or even
escape from the cell and attack targets far from the site of the original event. These aldehydes exhibit
great reactivity with biomolecules, such as proteins, DNA, and phospholipids, generating a variety of intra
and intermolecular covalent adducts. At the membrane level, proteins and amino lipids can be covalently
modified by lipid peroxidation products (hydoxy-alkenals). These aldehydes can also act as bioactive
molecules in physiological and/or pathological conditions. In addition this review is intended to provide
an appropriate synopsis of identified effects of hydroxy-alkenals and oxidized phospholipids on cell signaling,
from their intracellular production, to their action as intracellular messenger, up to their influence
on transcription factors and gene expression.
Compared to free radicals, these aldehydes are relatively stable and can diffuse within or even
escape from the cell and attack targets far from the site of the original event. These aldehydes exhibit
great reactivity with biomolecules, such as proteins, DNA, and phospholipids, generating a variety of intra
and intermolecular covalent adducts. At the membrane level, proteins and amino lipids can be covalently
modified by lipid peroxidation products (hydoxy-alkenals). These aldehydes can also act as bioactive
molecules in physiological and/or pathological conditions. In addition this review is intended to provide
an appropriate synopsis of identified effects of hydroxy-alkenals and oxidized phospholipids on cell signaling,
from their intracellular production, to their action as intracellular messenger, up to their influence
on transcription factors and gene expression.
Compared to free radicals, these aldehydes are relatively stable and can diffuse within or even
escape from the cell and attack targets far from the site of the original event. These aldehydes exhibit
great reactivity with biomolecules, such as proteins, DNA, and phospholipids, generating a variety of intra
and intermolecular covalent adducts. At the membrane level, proteins and amino lipids can be covalently
modified by lipid peroxidation products (hydoxy-alkenals). These aldehydes can also act as bioactive
molecules in physiological and/or pathological conditions. In addition this review is intended to provide
an appropriate synopsis of identified effects of hydroxy-alkenals and oxidized phospholipids on cell signaling,
from their intracellular production, to their action as intracellular messenger, up to their influence
on transcription factors and gene expression.
Compared to free radicals, these aldehydes are relatively stable and can diffuse within or even
escape from the cell and attack targets far from the site of the original event. These aldehydes exhibit
great reactivity with biomolecules, such as proteins, DNA, and phospholipids, generating a variety of intra
and intermolecular covalent adducts. At the membrane level, proteins and amino lipids can be covalently
modified by lipid peroxidation products (hydoxy-alkenals). These aldehydes can also act as bioactive
molecules in physiological and/or pathological conditions. In addition this review is intended to provide
an appropriate synopsis of identified effects of hydroxy-alkenals and oxidized phospholipids on cell signaling,
from their intracellular production, to their action as intracellular messenger, up to their influence
on transcription factors and gene expression.
n-6 and n-3 fatty acids, respectively.
Compared to free radicals, these aldehydes are relatively stable and can diffuse within or even
escape from the cell and attack targets far from the site of the original event. These aldehydes exhibit
great reactivity with biomolecules, such as proteins, DNA, and phospholipids, generating a variety of intra
and intermolecular covalent adducts. At the membrane level, proteins and amino lipids can be covalently
modified by lipid peroxidation products (hydoxy-alkenals). These aldehydes can also act as bioactive
molecules in physiological and/or pathological conditions. In addition this review is intended to provide
an appropriate synopsis of identified effects of hydroxy-alkenals and oxidized phospholipids on cell signaling,
from their intracellular production, to their action as intracellular messenger, up to their influence
on transcription factors and gene expression.