CIC   05421
CENTRO DE INVESTIGACIONES CARDIOVASCULARES "DR. HORACIO EUGENIO CINGOLANI"
Unidad Ejecutora - UE
artículos
Título:
Antioxidant and cardioprotective effects of Ilex brasiliensis: A comparative
Autor/es:
SCHINELLA GR; FANTINELLI JC; TOURNIER H; PRIETO JM; SPEGAZZINI E; MOSCA SM
Revista:
FOOD RESEARCH INTERNATIONAL
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2009 vol. 42 p. 1403 - 1409
ISSN:
0963-9969
Resumen:
Our objective was to compare the antioxidant properties and cardiovascular effects in ischemiareperfusion of leaves aqueous extracts of IlexIlex
brasiliensis (B) and Ilex paraguariensis (P). In vitro systems were used to assess the antioxidant properties of the extracts. Isolated rat hearts
were treated with both extracts before ischemia and myocardial function was assessed. Thiobarbituric acid reactive substances (TBARS)
concentration and reduced glutathione (GSH) were also measured. B extract showed higher total phenols and ascorbic acid contents and a higher
scavenging activity of peroxynitrite and ferric reducing antioxidant power (FRAP) than P extract. Postischemic systolic and diastolic functions
were improved after B and P treatment. Both extracts decreased TBARS and preserved GSH content. The present study demonstrates that an
aqueous extract of I. brasiliensis, similar to I. paraguariensis, protects the myocardium against ischemiareperfusion injury and attenuates
oxidative damage. These effects may be attributed to the potent antioxidant properties of the extract.