CIC 05421
CENTRO DE INVESTIGACIONES CARDIOVASCULARES "DR. HORACIO EUGENIO CINGOLANI"
Unidad Ejecutora - UE
artículos
Título:
PHOSPHOLAMBAN: A TINY PROTEIN WITH A PROMINENT ROLE IN THE
Autor/es:
MATTIAZZI A; MUNDIÑA WEILENMANN C; VITTONE L.
Revista:
Physiological Mini-Reviews
Editorial:
SAFIS
Referencias:
Lugar: Buenos Aires; Año: 2010
ISSN:
1669-5402
Resumen:
SUMMARY Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of â-adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.
