Nanodelivery of nitazoxanide: Impact on the metabolism of Taenia crassiceps cysticerci intracranially inoculated in mice

REAL, DANIEL; SOUZA LINO JUNIOR, RUY DE; VINAUD, MARINA CLAIRE; LIMA, NAYANA F; J SALOMON, CLAUDIO; FRAGA, CAROLINA MIGUEL; LEONARDI, DARÍO

Therapeutic Delivery

Future Medicine Ltd.

Lugar: Londres; Año: 2020 vol. 11 p. 329 - 339

2041-5990

To formulate nanocapsules and nanoemulsions of nitazoxanide (NTZ) and evaluate the metabolic effect on Taenia crassiceps cysticerci inoculated intracranially into mice. Materials & methods: NTZ nanosystems were formulated through solvent diffusion methodology. These nanoformulations were administered perorally and their impact on glycolysis, the tricarboxylic acid cycle and fatty acid metabolism in T. crassiceps cysticerci was investigated. Results: Gluconeogenesis and protein catabolism were significantly increased by the nanoformulations when compared with the control group and the NTZ-treated group. All the other metabolic pathways were inhibited by the nanoformulation treatments. Conclusion: The remarkable metabolic modifications that occur in this in vivo model through the application of these developed nanosystems confirm their capability to deliver NTZ into targeted tissues.