IQUIR 05412
INSTITUTO DE QUIMICA ROSARIO
Unidad Ejecutora - UE
artículos
Título:
A formal total synthesis of the marine alkaloid aaptamine
Autor/es:
LARGHI ENRIQUE L; OBRIST, BLAISE. V.; KAUFMAN, TEODORO S
Revista:
TETRAHEDRON
Editorial:
Elsevier
Referencias:
Año: 2008 vol. 64 p. 5236 - 5245
ISSN:
0040-4020
Resumen:
AbstractA new strategy for the synthesis of the benzo[de][1,6]naphthyridine derivative 2,3,3a,4,5,6-hexahydroaaptamine, which involves the construction of the isoquinoline ring after elaboration of the quinoline moiety, is described. Since 2,3,3a,4,5,6-hexahydroaaptamine has been previously synthesized as a key intermediate en route to the marine alkaloid aaptamine, access to this compound represents a formal total synthesis of the natural product.
