Structure-Activity Relationship for the Oxadiazole Class of Antibiotics

EDWARD SPINK; DERONG DING; ZHIHONG PENG; MARC A. BOUDREAU; ERIKA LEEMANS; ELENA LASTOCHKIN; WEI SONG; KATERINA LICHTENWALTER; PETER I. ODANIEL; SEBASTIAN A. TESTERO; HUALIANG PI; VALERIE A. SCHROEDER; WILLIAM R. WOLTER; NUNO T. ANTUNES; MARK A. SUCKOW; SERGEI VAKULENKO; MAYLAND CHANG; SHAHRIAR MOBASHERY

JOURNAL OF MEDICINAL CHEMISTRY

AMER CHEMICAL SOC

Lugar: Washington; Año: 2015 vol. 58 p. 1380 - 1389

0022-2623

The structure-activity relationship (SAR) for the newly discovered oxadiazole class of antibiotics is described with evaluation of 120 derivatives of the lead structure.  This class of antibiotics was discovered by in silico docking and scoring against the crystal structure of a penicillin-binding protein. They impair cell-wall biosynthesis and exhibit activities against the Gram-positive bacterium Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA) and vancomycin-resistant and linezolid-resistant S. aureus. 5-(1H-Indol-5-yl)-3-(4-(4-(trifluoromethyl)phenoxy)phenyl)-1,2,4-oxadiazole (antibiotic 75b) was efficacious in a mouse model of MRSA infection, exhibiting a long half-life, a high volume of distribution, and low clearance. This antibiotic is bactericidal and is orally bioavailable in mice. This class of antibiotics holds great promise in recourse against infections by MRSA.