Theoretical predictions for ionization and capture cross sections of DNA nucleobases impacted by light ions

C. CHAMPION; H. LEKADIR; M.E. GALASSI; O. FOJON; R. RIVAROLA; J. HANSEN

Salamanca

Conferencia; European Conference on Atoms, Molecules and Photons (ECAMP X); 2010

DNA lesions - and more particularly those involved in clustered damages - are nowadays considered of prime importance for describing the post-irradiation cellular survival. Indeed, these complex radio-damages may induce critical DNA lesions like double strand breaks whose relevance has been nowadays clearly identified in the radio-induced cellular death process. Thus, for predicting the human cancer risk from radiation exposure or even for modelling the cell-killing action during treatment plannings in radiotherapy, further theoretical models as well as experimental data on ion-induced collisions at the DNA level remain still today crucial. However, ions-DNA collisions have been only scarcely studied and we essentially find in the literature (semi)-classical models generally based on more or less sophisticated classical-trajectory Monte Carlo type approaches. Under these conditions, we have recently developed several theoretical quantum as well as classical models for describing the ion-DNA ionizing collisions including capture and ionization processes. We will here report the different predictions obtained in the 1st Born approximation, in the continuum-distorted-wave-eikonal-initial-state approximation and in the classical-trajectory Monte Carlo approach (FBA, CDW-EIS and CTMC, respectively).