PRELIMINARY STUDY OF ALTERATIONS IN HUMAN RED BLOOD CELLS BY IRRADIATION WITH HIGH ENERGY PHOTONS

EZEQUIEL ESTRADA; HORACIO CASTELLINI; BIBIANA RIQUELME; ANDREA ACOSTA

Recife

Congreso; VI Encontro Anual da Biofisica; 2019

Sociedade Brasileira de Biofisica

Transfusion-associated graft-versus-host disease can be prevented by treating cellular blood products with gamma irradiation. A wide range of gamma irradiation dose levels has been used in routine practice, but gamma irradiation dose of 25 Gy may be required to completely inactivate T cells in RBC units (Pelszynski, M. et al., 1994). This process decreases the survival of the transfused red blood cells, so it is crucial to understand the alterations caused by gamma irradiation to the erythrocyte membrane. For this reason, in this work we set out to measure the mechanical and aggregation parameters of the membrane of human red blood cells exposed to gamma photons in different doses in order to determine the possible alterations due to radiation.