In vitro effect of trigonelline on the erythrocyte aggregation in a model of diabetes

HERMANO MASCARO GROSSO; D'ARRIGO, MABEL; BIBIANA D. RIQUELME; PATRICIA BUSZNIEZ; MARTÍN A. TODERI

Recife

Congreso; Encontro Anual da Biofísica 2019; 2019

UFPE: Universidade Federal de Pernambuco

In the last few decades, a large number of medicinal plants popularly used for the treatment of diabetes have been studied around the world (Chang et al., 2013). The chemical characterization of plant components and the biological, pharmacological or toxicological activity of different plant extracts have been well studied; however, more research is necessary on the relationship between phytochemical components and their specific therapeutic action. Trigonelline is an alkaloid present in the leaves of Bauhinia sp., popularly known as ?cow-hoof?, and also in coffee and fenugreek seeds, which were used as an antidiabetic treatment by ancient civilizations. It has been found to reduce hyperglycemia, both in animals and humans, to protect pancreatic β-cells, and to increase the rate of insulin sensitivity