An optical chip aggregometer based on laser transmission to detect alterations in the aggregation of glycosylated RBC

NATALIA LERDA; PATRICIA BUSZNIEZ; MARTÍN A. TODERI; BIBIANA D. RIQUELME

San Diego

Simposio; Optics+Photonics 2017 - Novel Optical Systems Design and Optimization XX; 2017

SPIE

The study of erythrocyte (RBC) aggregation is of great interest because of its implications on human health, alterations in erythrocyte aggregation can lead to microcirculatory problems. An optical-chip based system was developed using laser transmission techniques in order to evaluate and characterize RBC aggregation. Studies are carried out with in vitro altered RBC by non-enzymatic glycosylation. Several samples were analyzed, and by computational data processing, characteristic parameters were found, describing RBC aggregation kinetics in order to improve the early detection in clinical environments of these anomalies, generally present in vascular diseases such as hypertension and diabetes.