Hemocompatibility study of new functionalized polycations tailored to modify the surface properties of red blood cells

GRANDFILS, C.; SEVRIN, CHANTAL; FORESTO, PATRICIA GLADYS; RELANCIO, M. F.; DANIELI, VIRGINIA; KOROL, ANA; DI TULIO, LILIANA; VALVERDE, JUANA ROSA; SONDAG-THULL, DANIELLE; RIQUELME, BIBIANA DORIS

Chalkidiki, Grecia

Congreso; International Conference on Nanomedicine; 2007

The term « polycations » refers to oligomers or organic polymers, from natural or synthetic origin carrying several positive charges at pH 7.4. These polycations can have molecular weight ranging from some hundred to several thousands of Da. One of the main objectives of our research project is to better understand the molecular interactions between well-controlled synthetic polycations and the membrane of the normal human red blood cells (RBC’s). On a long term basis, the purpose of this project will be to use these synthetic polycations functionalized with polyethylene glycol in order to mask the antigenic sites of human erythrocytes. The strategy will be to design copolymers that could self-assemble at the erythrocyte surface. One of the sequence of the copolymer will be a polycation able to be linked by ionic interaction to the glycocalyx. The other sequence, based on a polyethylene glycol moiety, should prevent both nonspecific interactions and specific recognition at the biological surface.