IFIR   05409
INSTITUTO DE FISICA DE ROSARIO
Unidad Ejecutora - UE
artículos
Título:
Erythrocytes Dynamic Viscoelasticity in Ò-thalassaemia minor
Autor/es:
PEREZ, S.; RIQUELME, BIBIANA; ACOSTA, I.; VALVERDE, JUANA R.; MILANI, A.
Revista:
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
Editorial:
IOS Press
Referencias:
Año: 2006 vol. 35 p. 311 - 316
ISSN:
1386-0291
Resumen:
β-thalassaemia is a hereditary hemolytic disease, in which each clinic phenotype encompasses a heterogenic group
of genetic alterations resulting in β-globin chain synthesis decrease or absence in red blood cells. Studies on β-thalassaemia
carriers suggest the existence of decreased red cell deformability. The erythrocyte deformability in the blood stream is a wellknown
fact regarding blood circulation efficiency. Red blood cells may be considered to be viscoelastic and their behavior may
be described according to complex viscoelastic parameters when they undergo oscillatory stresses. This dynamic behavior is
physiologically important due to the in vivo pulsatile blood flow. The aim of the present work was to evaluate complex erythrocyte
viscoelastic parameters in patients suffering from heterozygous β-thalassaemia in comparison with healthy individuals.
Our results reveal that even though thalassaemia erythrocytes show a decreased deformability in the stationary state, in a dynamic
state, hemorheological alterations are only evident at low oscillatory frequencies, i.e., at lower frequencies in contrast
with the normal heart rate (60 cycles/min = 1 Hz), producing no significant alterations at increased heart rate.-thalassaemia is a hereditary hemolytic disease, in which each clinic phenotype encompasses a heterogenic group
of genetic alterations resulting in β-globin chain synthesis decrease or absence in red blood cells. Studies on β-thalassaemia
carriers suggest the existence of decreased red cell deformability. The erythrocyte deformability in the blood stream is a wellknown
fact regarding blood circulation efficiency. Red blood cells may be considered to be viscoelastic and their behavior may
be described according to complex viscoelastic parameters when they undergo oscillatory stresses. This dynamic behavior is
physiologically important due to the in vivo pulsatile blood flow. The aim of the present work was to evaluate complex erythrocyte
viscoelastic parameters in patients suffering from heterozygous β-thalassaemia in comparison with healthy individuals.
Our results reveal that even though thalassaemia erythrocytes show a decreased deformability in the stationary state, in a dynamic
state, hemorheological alterations are only evident at low oscillatory frequencies, i.e., at lower frequencies in contrast
with the normal heart rate (60 cycles/min = 1 Hz), producing no significant alterations at increased heart rate.β-globin chain synthesis decrease or absence in red blood cells. Studies on β-thalassaemia
carriers suggest the existence of decreased red cell deformability. The erythrocyte deformability in the blood stream is a wellknown
fact regarding blood circulation efficiency. Red blood cells may be considered to be viscoelastic and their behavior may
be described according to complex viscoelastic parameters when they undergo oscillatory stresses. This dynamic behavior is
physiologically important due to the in vivo pulsatile blood flow. The aim of the present work was to evaluate complex erythrocyte
viscoelastic parameters in patients suffering from heterozygous β-thalassaemia in comparison with healthy individuals.
Our results reveal that even though thalassaemia erythrocytes show a decreased deformability in the stationary state, in a dynamic
state, hemorheological alterations are only evident at low oscillatory frequencies, i.e., at lower frequencies in contrast
with the normal heart rate (60 cycles/min = 1 Hz), producing no significant alterations at increased heart rate.in vivo pulsatile blood flow. The aim of the present work was to evaluate complex erythrocyte
viscoelastic parameters in patients suffering from heterozygous β-thalassaemia in comparison with healthy individuals.
Our results reveal that even though thalassaemia erythrocytes show a decreased deformability in the stationary state, in a dynamic
state, hemorheological alterations are only evident at low oscillatory frequencies, i.e., at lower frequencies in contrast
with the normal heart rate (60 cycles/min = 1 Hz), producing no significant alterations at increased heart rate.β-thalassaemia in comparison with healthy individuals.
Our results reveal that even though thalassaemia erythrocytes show a decreased deformability in the stationary state, in a dynamic
state, hemorheological alterations are only evident at low oscillatory frequencies, i.e., at lower frequencies in contrast
with the normal heart rate (60 cycles/min = 1 Hz), producing no significant alterations at increased heart rate.= 1 Hz), producing no significant alterations at increased heart rate.