“Characterization of microspheres formed in situ for controlled release”

LUDMILA N. TURINO; RODOLFO N. MARIANO; MARÍA I. CABRERA; RICARDO J.A. GRAU

Rosario, Santa Fe (Argentina)

Taller; 1º Taller de Órganos Artificiales, Biomateriales e Ingeniería de Tejidos (BIOOMAT 2009); 2009

Centro Binacional (Argentina – Italia) de Criobiología Clínica y Aplicada (CAIC), Facultad de Ciencias Bioquímicas y Farmacéuticas de la Universidad Nacional de Rosario y Sociedad Latinoamericana de Biomateriales, Ingeniería de Tejidos y Órganos Artificia

Trabajo DD4, A295, Biocell 33(3), 2009. ISSN: 0327-9545. Microspheres formed in situ are a novel and practical dosage form of the PLGA-based controlled release devices. They are prepared by dissolving the polymer and the drug in a solvent-system (phase 1) and then emulsified within a second solvent-system (phase 2). When the emulsion (pre-microspheres or microglobules) comes in contact with water or physiological fluids, organic solvents are diluted and the polymer precipitates entrapping the drug and forming spherical microparticles.