“Estradiol Permeation Studies in Chitosan Membranes. Effects of Cross-Linking Time”

LUCIANO N. MENGATTO; JULIO A. LUNA; MARÍA I. CABRERA

Rosario, Santa Fe (Argentina)

Taller; 1º Taller de Órganos Artificiales, Biomateriales e Ingeniería de Tejidos (BIOOMAT 2009); 2009

Organizado por: Centro Binacional (Argentina – Italia) de Criobiología Clínica y Aplicada (CAIC), Facultad de Ciencias Bioquímicas y Farmacéuticas de la Universidad Nacional de Rosario y Sociedad Latinoamericana de Biomateriales, Ingeniería de Tejidos y Ó

Trabajo DD2, A294, Biocell 33(3), 2009. ISSN: 0327-9545. Chitosan (CHT) is an abundant, low cost, biodegradable, biocompatible and non-toxic polysaccharide with good membrane and gel forming properties. Pharmaceutical formulations containing estradiol (E2) are used by women for the treatment of menopausal symptoms and menstrual disorders. This female hormone is also a contaminant present in wastewater effluent. The study deals with the analysis of the interaction between E2 and CHT, in particular the influence of cross-linking density of CHT membranes on swelling, sodium content and E2 permeation.  CHT powder was characterized for its degree of deacetylation (77 %) and viscosimetric molecular weight (600KDa). CHT membranes were obtained by a casting/solvent evaporation method and cross-linking with sodium tripolyphosphate (TPP).