N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms

GONZALEZ, V.D.G.; GONZALEZ, V.D.G.; GUGLIOTTA, LUIS MARCELINO; GUGLIOTTA, LUIS MARCELINO; GARCIA, V.S.; GARCIA, V.S.

LATIN AMERICAN APPLIED RESEARCH

PLAPIQUI(UNS-CONICET)

Lugar: Bahia Blanca; Año: 2019 vol. 49 p. 83 - 91

0327-0793

The aim of the present work was to synthesizesustained-release hydrogels based on N,N-dimethylacrylamide(DMA) to study the effect of thepolymer matrix structure and the solubility of drugson the load and release mechanisms. A series of crosslinkedDMA hydrogels were synthesized with differentmonomer concentration and crosslinker to monomerratio by free radical aqueous solution polymerizationat 37ºC using N,N-methylen-bis-acrylamide ascrosslinking agent. The effect of total monomer concentrationand degree of crosslinking on the water absorption,glass transition temperature values, mechanicalproperties, and load/release of differentdrugs was studied. Main results showed that: a) thestructure of the network, obtained by varying themonomer and crosslinking agent concentration, is afactor that governs the chemical and physical propertiesof the hydrogel (water absorption, glass transitiontemperature, storage and loss moduli, network parameters),b) the rate and amount of drug releasedfrom swellable hydrogels depend on both the degreeof hydrogel crosslinking and the water solubility ofthe drug. In all cases, as the concentration of thecrosslinker agent increased, the swelling capacity ofthe hydrogels was reduced and drugs with high solubilityin water were more easily released, probablydue to their greater affinity for the medium.