Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug release behavior

PABLO R. CORTEZ TORNELLO; GUSTAVO A. ABRAHAM; LÍVIA M. D. LOIOLA; MARIA B. FELISBERTI

RSC Advance

Royal Society of Chemistry

Lugar: Cambridge; Año: 2017 vol. 7 p. 161 - 172

2046-2069

Biocompatible amphiphilic copolymers are attractive candidates for the fabrication of electrospun scaffolds for tissue engineering and delivery of biologically active compounds. The amphiphilic block copolymers poly(L-lactide)-b-poly(ethylene oxide)-b-poly(L-lactide) (PELA) and poly(L-lactide)-b-poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-b-poly(L-lactide) (PEPELA) containing amorphous/crystalline and hydrophilic/hydrophobic blocks synthetized by ring-opening polymerization were electrospun to obtain non-woven fibrous scaffolds. Acetaminophen (AC) and celecoxib (CL) were used as hydrophilic and hydrophobic model drugs, respectively, to prepare drug-loaded scaffolds. The pure and drug-loaded scaffolds present morphology of randomly oriented fibers with integrated beads. The drug encapsulation and the release profiles were determined by ultraviolet-visible spectroscopy. Due to the amphiphilic nature of PELA and PEPELA, both hydrophilic and hydrophobic drugs could be entrapped within the polymeric scaffolds, allowing the design of drug delivery systems for specific applications. The combination of confocal Raman spectroscopy mapping and dynamic mechanical analysis revealed that AC drug is preferentially located into PEO phase and CL drug is fractionated between polyether and polyesters phases, being distributed all over the fibrous structure due to its hydrophobic character.