ACTIVATION OF M1 PROFILE IN MACROPHAGES OF EPIDIDYMAL ADIPOSE TISSUE IS ASSOCIATED TO AN IMPAIRMENT IN ADIPOCYTE FUNCTION.

RUMBO, MARTÍN; REY AMANDA; GAMBARO, SABRINA; GIOVAMBATTISTA , ANDRÉS; ZUBIRIA GUILLERMINA

Mar del Plata

Congreso; LXII REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC); 2017

SAIC

Obesity has become one of the main public health problems andis usually related to unbalanced diet consumption and sedentary lifestyle.In Argentina, from 2005 to 2013 the prevalence of obesityhas increased 42,5%, and is still growing. The aim of this study wasto evaluate the innate immune function in adipose tissue (AT) ofSwiss mice supplemented with a fructose rich diet (FRD) in drinkingwater (20%w/v) for 10weeks. Caloric intake and body weightwere recorded every 48hs. Epididymal adipose tissue (EAT) wasdissected and weighted at the end of the experiment and was processedfor histology, qPCR and flow cytometry (FACS) analysis.FRD mice showed an increased in caloric intake (P