IMBICE 05372
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA CELULAR
Unidad Ejecutora - UE
artículos
Título:
Clusters of Sirenomelia in South America
Autor/es:
ORIOLI I; MASTROIACOVO P; LOPEZ CAMELO JS; SALDARRIAGA W; ISAZA C; AIELLO H; ZARANTE I; CASTILLA EE
Revista:
BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
Editorial:
WILEY-LISS, DIV JOHN WILEY & SONS INC
Referencias:
Año: 2009 p. 112 - 118
ISSN:
1542-0752
Resumen:
BACKGROUND:OnehospitalinthecityofCali,Colombia,oftheECLAMC(Latin-AmericanCollaborativeStudyofCongenitalMalformations)network,reportedtheunusualoccurrenceoffourcasesofsirenomeliawithina55-dayperiod.METHODS:AnECLAMCroutineforclusterevaluation(RUMOR)wasfollowedthatincluded:calculationsofobserved/expectedratios,sitevisits,comparisonwithcomprehensivelycollectedlocal,SouthAmerican,andworldwidedata,clusteranalysis,andsearchforriskfactors.RESULTS:AllfourCalisirenomeliacaseswereborntomotherslivingina2km2area,inneighboringcommunes,withinthemunicipalityofCali.ConsideringthetotalbirthsofthecityofCaliasthedenominator,andbasedonECLAMCbaselinebirthprevalencerates(per100,000)forsirenomelia(2.25,95%CI:2.66,3.80),theclusterforthiscongenitalabnormalitywasunlikelytohaveoccurredbychance(observed/expectedratio55.77;95%CI:1.5714.78;p5.002).Noconsistentcommonfactorwasidentified,butvicinitytoanopenlandfillasthecausecouldnotberejected.AnotherECLAMChospitalinSanJusto,BuenosAires,Argentina,reportedthreefurthercasesbutthesedidnotseemtoconstituteanonrandomcluster.CONCLUSIONS:Themethodol-ogyusedtoevaluatethetwopossibleclustersofsirenomeliadeterminedthattheCalisirenomeliaclusterwasunlikelytohaveoccurredbychancewhereasthesirenomeliaclusterfromSanJustoseemedtoberandom.BirthDefectsResearch(PartA)85:112118,2009.2008Wiley-Liss,Inc.
