Methodological approaches to evaluate teratogenic risk using birth defect registries: advantages and disadvantages.

POLETTA FA, LÓPEZ CAMELO JS, GILI JA, LEONCINI E, CASTILLA EE, MASTROIACOVO P.

PLOS ONE

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2012 vol. 7 p. 265 - 271

1932-6203

Different approaches have been used in case-control studies to estimate maternal exposure to medications and the risk of birth defects. However, the performance of these approaches and how they affect the odds ratio (OR) estimates have not been evaluated using birth-defect surveillance programmes. The aim of this study was to evaluate the scope and limitations of three case-control approaches to assess the teratogenic risk of birth defects in mothers exposed to antiepileptic medications, insulin, or acetaminophen.