Evidence for resveratrol modulating Rac1 activation in microglial cells

FERNANDO CORREA; EVA WERTHEIMER; ANA JULIA TICCHI

Mar del Plata

Congreso; REUNIÓN ANUAL DE SOCIEDADES DE BIOCIENCIA 2020; 2020

SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA, SOCIEDAD ARGENTINA DE FISIOLOGÍA, SOCIEDAD ARGENTINA DE INMUNOLOGIA

Maternal immune activation (MIA) produces structural, metabolic, and epigenetic changes in the fetus resulting in long-term neurological and neuropsychiatric consequences. Microglial cells are one of the main effectors of the innate immune response in the CNS. Excessive microglial activation leads to CNS damage due to excessive production of pro-inflammatory mediators. It has been determined that Rac1 plays a central role in the inflammatory response and microglial neurotoxicity in the CNS.It has been demonstrated that resveratrol has anti-inflammatory, antioxidant properties that translate into neuroprotective effects in adults.