Stress induced cognitive deficit is differentially modulated in BALB/c and C57Bl/6 mice Correlation with Th1/Th2 balance after stress exposure

PALUMBO ML; CANZOBRE MC; PASCUAN CG; RÍOS H; WALD M; GENARO AM

JOURNAL OF NEUROIMMUNOLOGY

ELSEVIER SCIENCE BV

Año: 2010 vol. 218 p. 12 - 20

0165-5728

This work shows a comparative study on the effects of chronic mild stress upon learning and memory and immunity, in BALB/c and C57BL/6 mice. Stressed BALB/c, but not C57Bl/6 mice, showed a poor learning performance, morphological alterations in the hippocampus with an increase in oxidative stress. A correlation between poor memory performance and the increase of the Th2/Th1 balance was found. Our results suggest that vulnerability to cognitive deficit associated with stress exposition could be related to a differential regulation of Th1/Th2 cytokine balance, suggesting a better learning performance for individuals that produce Th1 type cytokine after stress exposition.