Emergency use of unproven clinical interventions outside clinical trials: ethical considerations

MASTROLEO, IGNACIO; UPSHUR, ROSS E.G.; REIS, ANDREAS; WORLD HEALTH ORGANIZATION (WHO) (AA.VV.)

World Health Organization

Lugar: Ginebra; Año: 2022 p. 43

978-92-4-004175-2

[La presente es una guía ética en la cual fui el escritor principal junto a un grupo de trabajo la cual se desarolló durante dos años y tiene aprox. 60 páginas]Emergency use of unproven clinical interventions outside clinical trials including "off-label" interventions has surged during the COVID-19 pandemic, with unjustified, unconstrained use of unproven interventions, which raises serious ethical concerns. This document is intended to provide a reminder and an updated version of the ethical framework for emergency use of unproven clinical interventions outside clinical trials, the MEURI ethical framework, which is a collaborative project of WHO that began in 2014 and a normative product of WHO for its 194 Member States.