INVESTIGADORES
LUCANGIOLI Silvia Edith
libros
Título:
Cholestasis
Autor/es:
LUCANGIOLI S.; TRIPODI V.
Editorial:
InTech
Referencias:
Año: 2012 p. 100
ISSN:
978-953-51-0043-0
Resumen:
The aim of this book is the study of cholestasis from different points of view.
Cholestasis is one of the most common and devastating manifestations of hereditary
and acquired liver diseases. Since the importance of the disease has been made aware,
there have been many research works, providing an increase of information.
Identification of the molecular defect in cholestasis is not only important for diagnostic
reasons, but also to emphasize that impaired transporter function has pathological
consequences. Indeed, it is now becoming clear that impaired or down regulated
transporter function is also involved in the pathogenesis of acquired cholestatic
syndrome.
Linked to the diagnosis of cholestasis, an important area to study is the serum bile acid
profiles. In this sense, a great development of analytical methodologies has allowed
the relationship between them and the different types of cholestasis to be studied. The
proper interpretation of serum bile acid profiles provides medical management
against the disease.
Different models of induction of cholestasis have been designed in order to deepen
understanding and clarify protective mechanisms, which could contribute to
improved treatment of the pathology.
The complete understanding of cholestasis will provide an efficient treatment and an
overall improvement in the patient life quality.