3D MODELLING OF MAMMALIAN EMBRYOS AND ORGANS

GARAGNA S; ARECHAGA J; CEBRAL E; ZUCCOTTI M

Frontiers Editorial Office

Año: 2021 p. 188

978-2-88971-607-4

?Editorial: 3D modelling of Mammalian Embryos and Organs? The main scope of this Special issue was to gain understanding on how tissues and organs are arranged into integrative hierarchical levels of complexity, from the molecular to the morphological organization. To understand the underlying complexity of the relationships among these levels during morphogenesis or in the adult we must learn how to resolve single-cell spatial relationships in the three-dimensional (3D) organisation of tissues, organs and even of the whole organisms.Each paper in this ?Frontiers? special issue contributes to deepen our understanding on the dynamics and mechanisms of development and differentiation in the complexity of the 3D architecture of embryos, intact organs or organoids.Five out of thirteen contributions, which include Original articles, Reviews, Perspectives, Hypothesis and Theories, focused on intact tissues or organs. In the other eight papers, 3D stem cell culture systems, coupled with advanced microscopy approaches, are exploited to recapitulate morphogenesis and differentiation with the creation of gastruloids, spheroids or organoids where the cellular organisation and function of specific tissues and organs are mimicked. The main content of each contribution is briefly described below starting with those papers focusing on organs and then with those that have used stem cell cultures in 3D.