DEVELOPMENT OF SARCOMA E-100 IN RATS FED WITH A SUCROSE-RICH DIET

CILENZO, A; CATELANI, BT; CHIARALUCE, F; BARRANCO, MM; ALTAMIRANO, A; GIMENEZ MOLINILLO, G; IGLESIAS, M; ZECCHINATI, F; PERDOMO, VG; VILLANUEVA, SSM; ARIAS, P; GARCÍA, FABIANA

Rosario

Congreso; XVIII Congreso y XXXVI Reunión Anual de la SOCIEDAD DE BIOLOGIA DE ROSARIO; 2016

SOCIEDAD DE BIOLOGIA DE ROSARIO

Insulin resistance (IR) is associated with an increased prevalence of different types of cancer; however, there is no data re garding the prevalence of sarcomatous tumors in subjects with IR. Our aim was to evaluate tumor growth in controls and in IR rats (fed with 30 % sucrose W/V) (SRD) after subcutaneous inoculation of SE-100 sarcoma cells. Study groups were: G1: control animals + vehicle; G2: control animals + SE-100, G3: IR animals + vehicle; G4: IR animals + SE-100. Results: Weight gain (expressed in g) was higher in animals maintained under SRD, G1 (104.4 ± 5.1), G2 (96.8 ± 10.3), G3 (145.7 ± 11.7) and G4 (142.7 ± 10.2) (G3 and G4 p