An antitumor triazolyl peptidyl penicillin derivative inhibits Wnt/β-catenin pathway and angiogenesis

BARRIONUEVO E; CORNIER P.G.; DELPICCOLO CM; BOGGIÁN D.B; MATA E.G.; L. P. ROGUIN.; BLANK VC

Mar del Plata

Congreso; LXIII Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica, LXVI Reunión Anual de la Sociedad Argentina de Inmunología, Reunión Anual de la Sociedad Argentina de Fisiología; 2018

SAIC, SAI, SAFE

In a previous work, we demonstrated that TAP7f, an antitumor penicillin derivative formed by penicillin linked to the dipeptide Phe-Leu through a triazole group, exhibited antimetastatic properties through the inhibition of cell adhesion, migration and invasion of highly metastatic melanoma B16F10 cells. This penicillin derivative also inhibited MMP-2 and 9 expression and activity. In order to extend the research on TAP7f antimetastatic properties, we investigated the effect of this derivative on Wnt/β-catenin pathway. By Western blot analysis, we found that a 10 µM concentration of TAP7f inhibited 51±11% (p