Alterations in intermediate metabolism and aorta aorta morphology induced by zinc deficiency and/or high fat diet during growth.

MEDINA AGUSTINA; GIACOMAZZI, JULIA; PAEZ DIAMELA TATIANA; MORIONDO MARISA; ZAGO V; SCHREIER L; MENDES GARRIDO F; CANIFFI, C; ELESGARAY R; ARRANZ C; TOMAT AL

CABA

Congreso; Reunión conjunta SAIC-SAI-AAFE-NANOMED; 2021

Sociedad Argentina de Investigación Clínica

Introduction: Zinc deficiency can coexist with overweight and obesity during growth predisposing to metabolic disorders in adult life.Objective: To evaluate, in adult male rats, alterations in intermediate metabolism and aorta morphology induced by fetal and postnatal zinc deficiency and/or high fat diet during post weaning life. Methodology: Female Wistar rats received low (L:8ppm) or control (C:30ppm) zinc diets from pregnancy to offspring weaning. C male offspring continued with C(C) or HFD (60% of total calories) (CH) diets. L offspring were fed L(L) or L and HFD(LH) diets. At day 81, we determined blood oxidative stress, glucose tolerance test (GTT), lipid profile, plasmatic adiponectin levels and thoracic aorta morphology. Two way ANOVA, Bonferroni post-test, mean±SEM, *p