INVESTIGADORES
FERNANDEZ Gabriela Cristina
congresos y reuniones científicas
Título:
Myeloid immature cells (gr-1+cd11b+) acquire their inhibitory properties in the bone marrow, and migrate to lymph nodes to exert their function
Autor/es:
LANDONI V.I; MARTIRE-GRECO D; RODRIGUEZ-RODRIGUES N; CHIARELLA P; SCHIERLOH P.; REARTE B.; ISTURIZ M.A; FERNÁNDEZ G C
Lugar:
Mar del Plata
Reunión:
Congreso; LIX REUNIÓN CIENTÍFICA ANUAL Sociedad Argentina de Investigación Clínica. LXII REUNIÓN ANUAL Sociedad Argentina de Inmunología; 2014
Institución organizadora:
SAIC/SAI
Resumen:
Lymph nodes (LN) from LPS-immunosuppressed (IS) mice
have a decreased T cell (Ly) proliferation, associated to an increment
of myeloid derived suppressor cells (MDSC, Gr-1+CD11b+).
Moreover, MDSC from bone marrow (BM) of IS mice also exhibited
an inhibitory activity towards Ly proliferation. Our aim was
to evaluate whether MDSC acquire their immunosuppressive
properties in BM and then migrate to LN to exert their function,
and evaluate their inhibitory mechanisms. We found that the
inhibition of Ly proliferation by BM-IS was accompanied with an
increase in cells expressing inducible nitric oxide (NO) synthase
(Gr-1+CD11b+iNOS+) and reactive oxygen species (ROS) (Gr-
1+CD11b+DHR+) determined by FACS (p