GERANIOL (GO) PREVENTS INTESTINAL MRP2 DOWN-REGULATION IN RATS WITH FRUCTOSE-INDUCED METABOLIC SYNDROME (MS)

ZECCHINATI FELIPE; LONDERO ANA SOFÍA; ARANA MAITE ROCÍO; TOCCHETTI GUILLERMO; PERDOMO VIRGINIA; BARRANCO MARÍA MANUELA; CILENZO ANAHÍ; MOTTINO ALDO DOMINGO; GARCÍA FABIANA; VILLANUEVA SILVINA

Mar del Plata

Congreso; LXI REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC); 2016

Intestinal Mrp2 is an ABC transporter that limits the absorption of xenobiotics orally ingested, thus acting as a biochemical barrier. MS is a pathological condition characterized by insulin resistance, hyperinsulinemia and dyslipidemia as well as by chronic inflammation and oxidative stress (OS). In previous studies we observed that MS-like conditions induced by fructose in drinking water (10% v/v, during 3 weeks: FRU), reduced the expression and activity of intestinal Mrp2 in rats. We here evaluated the effect of GO (250 mg/kg/day; p.o), a monoterpene with antioxidant and anti-inflammatory properties, in preventing fructose-induced Mrp2 alterations. After 2 weeks of co-treatment, GO prevented down-regulation of Mrp2 protein evoked by MS, as detected by western blotting (C: 100%, FRU: 23%, FRU-GO: 107%, P