Effects of early treatment with cannabidiol on emotional and cognitive alterations induced by an animal model of fetal alcohol spectrum disorder (FASD)

FRANCISCO NAVARRETE RUEDAS; AMAYA AM AUSTRICH-OLIVARES; ANI GASPARYAN; GABRIELA B. ACOSTA; JORGE MANZANARES ROBLES

Congreso; 20th WPA World Congress of Psychiatry; 2021

OBJECTIVESThis study evaluated the effects of cannabidiol (CBD) on emotional and cognitive impairments induced by an animal model of Fetal Alcohol Spectrum Disorder (FASD).METHODSFemale C57BL/6J mice underwent an ethanol voluntary consumption (VC) experiment and were selected according to ethanol 10% intake and percentage of preference values before to be crossed. From gestational day 7 until post-natal day 21, mothers were administered 3 g/kg of ethanol (p.o., twice a day). Immediately after weaning, pups began the treatment with CBD 30 mg/kg (i.p.) for 8 weeks. Anxiety- and depressive-like behaviors were evaluated with the elevated plus maze (EPM), tail suspension (TS) and novelty suppressed feeding (NSF) tests. Also, pre-attention and aversive memory were analyzed with the prepulse inhibition (PPI) and step-down inhibitory avoidance (SDIA) paradigms, respectively.RESULTSMice exposed to ethanol showed increased levels of anxiety- and depressive-like behaviors in the EPM and the TS and NSF tests (P