(‒)-Epicatechin modulates systemic and renal modifications in a rat model of endotoxemia

FISCHERMAN L; HID EJ; GALLEANO M; FRAGA CG

Congreso; SFRR-E 2019 Annual Meeting ?Redox Homeostasis: from Signaling to Damage?; 2019

SFRRE

Endotoxemia, characterized by systemic inflammation, is a major cause of acute kidney injury. In this work, Sprague-Dawley male rats, pretreated for 4 days with control diet or with diets supplemented with 20 (low-level, LLE) or 80 (high-level, HLE) mg (−)-epicatechin (EC)/kg of body weight/day, were challenged with bacterial lipopolysaccharide (LPS) (i.p. 4 mg/kg BW) and sacrificed 6 h post LPS administration. In LPS-treated endotoxemic animals, plasma GPT, GOT and LDH levels were slightly or non-affected; nitric oxide (NO) levels in blood, measured by EPR, increased significantly, and HLE avoided 41% (p