Control of Clostridium perfringens necrotic enteritis by tannins added to the diet.

REDONDO, L M; REDONDO, E A; DELGADO, F; LASALA, L; PEREYRA, A; GARBACCIO, S; CHACANA, P; FERNANDEZ MIYAKAWA, ME

Palm Cove

Congreso; 8º ClostPath International Meetings on the Molecular Biology and Pathogenesis of Clostridia.; 2013

Clostridium perfringens (CP) necrotic enteritis has been controlled through the use of antibiotic feed additives. Banning of antimicrobial growth promoters has been accompanied by increased incidence of necrotic enteritis, which has become economically significant for the broiler industry. Previous works have indicated that selected tannins have in-vitro bacteriostatic, bactericidal and antitoxin activities against CP, suggesting that tannins could be a potential tool to control related diseases. The objective of this study was to determine the effect of tannins on CP necrotic enteritis and the effect on growth performance. For this objective, we developed a model of necrotic enteritis in broiler which reproduced consistently lesions and clinical signs without the use of predisposing factor. In this model, animals were supplemented with tannins (A, B, and blend of A+B) in regular feed 3 days before the challenge and maintained up to one week later. Animals were challenged at day 14 after birth and euthanized at day 19 and 30. At day 30, animals treated with the different tannins, showed 5-22% of weight gain compared to challenged control. CP counting in poultry bed was 104 in the challenged group and was 104,