Chalcones as inhibitors of phytopathogenic fungal in-vitro development

SANCHEZ C; ARDANAZ CE; MASCOTTI ML; KURINA-SANZ M; ORDEN AA

MENDOZA

Congreso; XXVII Reunión Científica anual de la Sociedad de Biología de Cuyo; 2009

SBC

Coumarines are a group of compounds fully distributed in plants, such as in Umbelliferae/Apiaceae and Rutaceae familes, like glicosides or in their free forms. It has been reported for them antifungal, antibacterial and, the most well-known, anticoagulant activity, the last one as a consequense of a defense mechanism against predators. The objetive of this work was to evaluate antibacterial activity of 5-hidroxycoumarin (1), 3-acylcoumarin (2), coumaranone (3), 4-hidroxycoumarin (4), coumarin (5), 3-hidroxycoumarin (6), 7-hidroxycoumarin (7), 6-hidroxycoumarin (8), against Lactobacillus acidophilus, Bifidobacterium bifidum and Bacillus subtilis, from a commercial liophilyzated of gram+ bacterium. The results obtained, expresed as MIC (minimal inhibition concentration), are: coumaranone (3) >250μg/ml, 3-acylcoumarin (2) and 6-hidroxycoumarin (8) 250μg/ml, 5-hidroxycoumarin (1) 125μg/ml, coumarin (5) 62.5μg/ml, 4-hidroxycoumarin (4), 7-hidroxycoumarin (7) and 3-hidroxycoumarin (6)