20. Immunomodulatory Effect of 7-oxo-DHEA on Mycobacterium tuberculosis-Specific Responses in the context of HIV Coinfection.

VECCHIONE, MARÍA BELÉN; MELUCCI GANZARAIN, CLAUDIA DEL CARMEN; SUAREZ, GUADALUPE; SUED, O.; LAUFER N; MATA ESPINOSA, DULCE; BARRIOS PAYÁN, JORGE; MARQUINA, BRENDA; HERNANDEZ PANDO, ROGELIO; BRUTTOMESSO, ANDREA; MARIA FLORENCIA QUIROGA

Whistler, British Columbia

Simposio; Keystone Symposia on Molecular and Cellular Biology. Tuberculosis: Translating Scientific Findings for Clinical and Public Health Impact; 2018

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), an infectious disease that currently affects approximately one third of the world'spopulation and it constitutes one of the top 10 causes of deaths worldwide. The type of individual's immune response will determine disease progression or itsdevelopment into a chronic infection. Particularly, the risk of developing TB in human immunodeficiency virus (HIV)-coinfected patients is 20 to 30 times higherthan those without HIV infection. The synergistic interplay between these two pathogens accelerates a decline in immunological functions.TB treatment in people coinfected with HIV and Mtb (HIV-TB) is challenging and it has a prolonged duration, mainly due to failure of the immune system toprovide an adequate support for the therapy. Novel host-directed therapy could be discovered by studying and identifying factors that lead to diseaseprogression. Thus, the aim of this work was to study the role of the hormone 7-oxo-dehydroepiandrosterone (7-oxo-DHEA) as modulator of the anti-tuberculousimmune response in the context of HIV-TB coinfection. We compared the results with the adrenal hormone DHEA, which has previously been reported asimmunomodulator.