Immune variations throughout the course of tuberculosis treatment and its relationship with adrenal hormone changes in HIV-1 patients co-infected with Mycobacterium tuberculosis.

VECCHIONE, MARÍA BELÉN; GIANNONE, DENISE ANABELA; ANGERAMI, MATIAS TOMAS; LAUFER, NATALIA; SUED, OMAR; QUIROGA MARIA FLORENCIA

Simposio; Tuberculosis: Science Aimed at Ending the Epidemic; 2020

Purpose: Risk of developing active TB among HIV-coinfected (HIV-TB) patients is 19 times higher than in HIV-negative individuals. Host´s immune response determines resolution or dissemination of TB infection. We aimed to identify immuno-endocrine responses over a six-month follow-up of anti-tuberculous (anti-TB) treatment in HIV+ individuals that were associated with control of TB.Methods: Plasma levels of cortisol, DHEA and DHEA-S (DHEA sulfate), percentages of CD4+ regulatory T cell subsets and number of IFN-γ-secreting cells were determined. Several cytokines, chemokines and C-reactive protein (CRP) levels were measured. Results were analyzed, correlated with clinical data and compared to similar data from HIV-1-monoinfected individuals, HIV infected individuals with latent TB infection and healthy donors.Results: Throughout the course of anti-TB/HIV treatment, reduction of viral load (p