Glyphosate exposure induces neurobehavioral alterations in developmental rats.

LUNA, SEBASTIAN; BORGATELLO, CONRADO; ROSSO SILVANA

Rosario

Congreso; Reunión Anual de la Sociedad Argentina de Fisiología; 2020

Sociedad argentina de Fisiología SAFIS

The right functioning of the brain relies on the precise connectivity of neuronal networks. Nowadays, there is growing evidence of the high vulnerability of developing nervous system to environmental contaminants. Glyphosate-containing herbicides are the most used agrochemicals in the world, particularly on genetically modified plants. Previous studies have demonstrated that glyphosate (Glyph) induces neurotoxicity in mammals. Therefore, in this work, we studied the potential effect of Glyph on nervous system during development. Wistar rats postnatal day (PND) 7 were exposed subcutaneously to Glyph (35 or 70 mg/Kg) or vehicle (PBS) every 48 hours for 3 weeks (critical period of synaptogenesis). Then, we performed behavioural evaluation through different tests, such as, Open Field for locomotor activity and Novel Object Recognition and Water Maze for learning and memory examination. Finally, animals were sacrificed on PND35 and hippocampi were dissected for biochemical analysis. We found that Glyph exposed rats showed a decrease in motor activity (p