Glyphosate neurotoxicity in adult rats: analysis of neuromotor and behavioral parameters.

LUNA, SEBASTIAN; BORGATELLO, CONRADO; ROSSO S.

virtual

Congreso; ANNUAL MEETING OF BIOSCIENCE SOCIETIES 2020; 2020

Sociedades de Fisiología, inmunología e inv. clinica

The neurotoxicity caused by to glyphosate (Glyph) exposures has long been described in several studies, however there are few studies that extensively evaluate an important variable such as motor activity. Dysfunctions on motor activity induced by pesticides can be determined with relatively simple techniques and may be used as a component of the FOB (Functional Observational Battery). The aim of this experiment was to determine the neuro-motor and behavioral changes caused by sub-acute administration of Glyph. Male Wistar rats 80-90 days old were treated subcutaneously with a Glyph solution (Sigma, without adjuvants) in saline phosphate buffer (PBS) (s.c.). One dose of 70 mg/kg was tested every 48 hours for 14 days, (n=12). A group of rats was used as control (n=12) that was injected only with the vehicle. Body mass was recorded daily. Two tests were carried out in control and treated animals to determine the locomotor activity: open field and elevated plus maze, according to established protocols. The test recording was done through video camera, and then the data and statistical analysis were carried out by t student method. We found that Glyph exposed rats showed a decrease in motor activity time (p