A MATERNAL DIET ENRICHED IN OLIVE OIL PREVENTS PROINFLAMMATORY ALTERATIONS IN TERM PLACENTAS FROM DIABETIC PREGNANT WOMEN.

DÍAZ, ESTEBAN; CAPOBIANCO, EVANGELINA; FAZIO, MARÍA VICTORIA; JAWERBAUM, ALICIA; GOMEZ RIBOT, DALMIRO; MACCHI, SILVIA

Buenos Aires

Congreso; International Federation of Placenta Associations; 2019

International Federation of Placenta Associations

Objectives: Gestational diabetes mellitus (GDM) induces a pro-inflammatory intrauterine environment and alters placental function. Peroxisomeproliferator-activated receptors (PPARs) are ligand activated transcription factors that regulate the expression of genes involved in antiinflammatoryprocesses. Olive oil (OO) is enriched in oleic acid, a PPAR activator.We hypothesize that a maternal diet enriched in OO is capable of activating PPAR pathways and reducing pro-inflammatory markers in term placentas.Methods: Healthy patients (Control: C) and patients with GDM (n¼40) were enrolled after signing an informed consent. All the patients followedthe WHO recommended diet for pregnancy, and a group of patients with GDM received a supplementation of 26mL of OO (GDMO) daily since week24 of gestation until delivery. At delivery, placental villous explants were obtained and stored for Western blot, immunohistochemical and zymographyanalysis, and evaluation of nitrates/nitrites (index of nitric oxide production).Results: PPARa levels were decreased in the placentas of the GDM group (27%, p