Stress affects predictive learning in a contextual fear memory

FERNANEZ PABLO; FERRER MONTI, ROQUE I.; BUENO, ADRIAN MARCELO; MARTIJENA, IRENA; ALFEI, JOAQUÍN MATÍAS; MOLINA, VICTOR A.

Carlos Paz

Congreso; Congreso Anual de la Sociedad Argentina de Neurociencias; 2019

A growing amount of evidence has shown that consolidated fearmemories can enter a transient labile phase under certain conditions.Prediction error, defined as the discrepancy between an expectationand what the organism experiences is crucial for triggering thedestabilization/reconsolidation process. On the other hand, stressfacilitates the formation of a fear memory resistant to destabilization.However, the role of stress on prediction error has not beeninvestigated. The goal of the present study was to investigate theeffect of stress on the temporal prediction error in contextual fearconditioning in rats.