Clarithromycin:N-acetylcysteine co-amorphous combination as alternative to improve solubility and antibiofilm activity

ZOPPI A; CAMPOS M; GUALDESI S; LONGHI MR; AIASSA V

Mar del Plata

Congreso; Reunión anual de Sociedades Biocientíficas-SAIC-SAFE-SAB-SAP 2019; 2019

Clarithromycin (CLM) is a semisynthetic 14-member macrolide exhibiting a broad in vitro antibacterial spectrum and a variety of clinically diagnosed infections. It is a water-insoluble base (pKa = 8.8) and with pH-dependent solubility. One approach that has been explored to overcome the problem of poor aqueous solubility is by using a pharmacologically relevant combination of two drugs in the preparation of co-amorphous systems.