LSP1 KO tumor-bearing mice have a higher frequency of functional cross-presenting dendritic cells in the spleen

PASCUAL, MARÍA MERCEDES; DHO, NICOLÁS DANIEL; ACLAND STRACK, RACHEL PAOLA; CRESPO, MARÍA INÉS; PISTORESI, MARÍA CRISTINA; MALETTO, BELKYS A; MORÓN, GABRIEL

Mar del Plata

Congreso; LXVI Reunión Anual de la Sociedad Argentina de Inmunología (SAI); 2018

Sociedad Argentina de Inmunología

All leukocytes and endothelial cells from human and mice express a 52kDa cytoplasmic F-actin binding phosphoprotein, called Leukocyte-specific protein 1 (LSP1). This protein is known as an important actin cytoskeleton-regulator. LSP1 polymorphisms or downregulation are considered risk factors for some types of cancer. Using the MO5 melanoma model, our group has shown that LSP1 deficient mice have an impaired control of melanoma growth. In order to study the role of LSP1 in antitumor immune response, WT and Lsp1-/- mice were subcutaneously-injected with 105 MO5 cells and followed-up until day 15 or 17 depending on the experiment. At these time points, tumors in Lsp1-/- mice were bigger than in WT controls (p